Selecting a Dissolution Medium for Solid Oral Products
نویسنده
چکیده
Choice of a dissolution medium is an important and critical variant for drug dissolution testing. The reported choices range from a simple solvent (water) to complex solutions, often drug and/or product dependent. However, making a choice is not so simple or straightforward, but confusing and often scientifically or logically not convincing or valid. This article provides a discussion in this regard leading to suggestions for selecting an appropriate dissolution medium.
منابع مشابه
Land O’Lakes Pharmaceutical Analysis Conference
Dissolution testing measures the rate of drug substance release into solution, impacting the extent of drug absorption. Drug manufacturers and regulatory agencies use dissolution testing to identify drug products that do not meet the desired clinical performance. Formulation composition and manufacturing processes can impact the material attributes of a drug product, which directly affect the d...
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